China Education Equipment Purchasing News: According to Biological News, Professor Liu Jing of Tsinghua University published the whole body hyperthermia mechanism of tumor in the form of a cover article in the new issue of the International Journal of Hyperthermia in an authoritative journal Research results. In the new article, the authors established a microwave-induced fever-like systemic hyperthermia paradigm, and systematically explored the role of systemic hyperthermia through the evaluation of the efficacy of melanoma lung metastasis in mice and the detection of immune marker proteins. "The risk of surgery can be minimized to establish a standardized treatment procedure and also provide new ideas for the ongoing immunotherapy and chemotherapy."
According to the news, many tumors are clinically found in the middle and late stages, and traditional therapies are often powerless. For this kind of mid-advanced cancer with metastatic characteristics, whole body hyperthermia is a systemic therapy with great development prospects, which has the advantages of high safety and low side effects. However, in the past, there has been insufficient research and corresponding high-performance treatment equipment. To a large extent, it restricts the large-scale clinical application of this important method. Through in-depth study of various biological effects and mechanisms of whole body hyperthermia, clarify the most critical treatment factors, can minimize the risk of surgery, thereby establishing a standardized treatment procedure, and also providing immunotherapy and chemotherapy that are in progress New ideas.
In the new article, the authors found that when systematically exploring the role of systemic hyperthermia, whether administered alone or in combination with chemotherapeutic drugs, specific doses of systemic hyperthermia under this paradigm can significantly inhibit B16-F10 lung in mice Metastatic melanoma growth. Biomarker testing after 14 days of treatment showed that tumor growth was significantly inhibited under the combined action of multiple pathways (especially factors such as increased immune response, decreased tumor cell proliferation rate, increased tumor cell apoptosis, and inhibition of neovascularization). Whole body hyperthermia can inhibit the metastasis and spread of tumor cells by increasing the formation of intercellular adhesion molecules and fibers at the tumor site. It can also increase the number of CD8 + T cells by reducing peripheral CD4 + T cells, thereby enhancing cellular immune function.
According to reports, Liu Jing, a professor at the Department of Biomedical Engineering of the School of Medicine of Tsinghua University and a double-employed researcher at the Institute of Physical and Chemical Technology of the Chinese Academy of Sciences, is leading the research. In his early years, he obtained a Bachelor of Engineering, a Bachelor of Science and a PhD in Engineering from Tsinghua University; he was a postdoctoral fellow at Purdue University and a senior visiting scholar at MIT. He was successively selected into the Hundred Talents Program of Chinese Academy of Sciences / Tsinghua University. The research field involves low-level biomedicine, tumor hyperthermia, advanced energy, low-cost medical treatment and micro / nano technology, and makes a series of original contributions. Published more than 200 papers in domestic and foreign journals and international conferences; applied for more than 90 patents.
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