Nature's new sub-scientific Scientific Reports recently published online research results of non-random damage to mitochondrial DNA caused by ionizing radiation from researchers in the Institute of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences. The researchers comprehensively analyzed the regional damage caused by ionizing radiation to the entire sequence of mitochondrial DNA through molecular biology, and found that such damage is non-random. Subsequently, bioinformatics analysis was used to further clarify the internal mechanism of non-random damage to mitochondrial DNA caused by ionizing radiation.
In the field of radiobiology research, related research has long discovered that the DNA damage caused by ionizing radiation is non-random, but the internal mechanism that causes this phenomenon has not been elucidated. Researchers of the Near Institute of Biotechnology selected the only extranuclear genetic material in eukaryotic cells, mitochondrial DNA, as the research object, and used fluorescent quantitative PCR to analyze the regional damage of mitochondrial DNA caused by ionizing radiation. The results showed that the sequence of the mitochondrial DNA control region was the most sensitive to ionizing radiation, while the damage to the coding region of the mitochondrial DNA was relatively small (Figure 1).
To further clarify the cause of this random DNA damage, researchers used bioinformatics to analyze the sequence structure of mitochondrial DNA and found that GGG sequences were selectively enriched in the mitochondrial DNA control region (Figure 2). According to reports, the GGG sequence is an important element that mediates charge transfer on the double-stranded DNA and acts as a "charge trap." This explains why ionizing radiation selectively damages the mitochondrial DNA control region sequence. To determine the importance and conservation of charge transfer in non-random damage to mitochondrial DNA, the researchers selected 107 complete mitochondrial DNA sequences of vertebrates for analysis. As a result, it was found that GGG elements were enriched in the mitochondrial DNA control region of warm-blooded animals, but its content was very low in warm-blooded animals (Figure 3). This finding further illustrates the important role of charge transfer in the evolution of species' mitochondrial DNA.
This work was funded by the National Key Basic Research and Development Program 973 Project (2010CB834202) and the National Natural Science Foundation of China Key Project (10835011).
Figure 1 Ionizing radiation causes dose-dependent and region-specific mitochondrial DNA damage
Figure 2 Bioinformatics screening of the distribution of GGG fragments on mitochondrial DNA
Figure 3 GGG elements selectively enrich in the mitochondrial DNA control region of warm-blooded animals in vertebrates
Spunlace Nonwoven Fabric is widely used to make medical curtain, surgical mask, garment lining cloth, instrument and instrument advanced cloth, towel, cosmetic cotton, mask covering material, etc. Its advantages includes:
1. Environmental protection, biodegradable;
2. Dust-free, no fiber shedding in use to ensure the quality of wiping;
3. The fiber net is uniform and has excellent vertical and horizontal tension;
4. The material is soft and will not scratch or damage the surface of the cleaning objects;
5. Super absorbent capacity, four times faster than ordinary cotton cloth;
6. Remove water stains and oil stains efficiently.
Product Features
1.Close appearance to the textile
2.High strength,Low Lint
3.High hygroscopicity,quick moisture absorption
4.Good air permeability
5.Soft hand feel,good drapability
6.Washing Durability
7. Chemical Free
8. Eco-friendly
Mesh Spunlace
With advanced Spunlace equipment and high quality fibre material, the mesh spunlace have several features: uniformity web, handle embonpoint, mesh clarity and high mightiness. Mesh spunlaces have several types as the number of mesh in one square centimeter: 9 meshes, 10meshes, 12 meshes, 18 meshes, 22 meshes, 26 meshes. And the mesh also have several types: round, square, rhombus and so on.
Mesh Spunlace
Mesh Spunlace,Wipes Roll Materials,Mesh Spunlaced Fabric,Mesh Spunlaced Non Woven
Zhejiang Youquan Care Products Technology Co., Ltd. , https://www.youquancare.com