Detection of polymer impurities of β-lactam antibiotics

The inevitable trend of detecting polymer impurities in β-lactam antibiotics.

SEF Technology Size Exclusion Column
SRT® (5 μm), Zenix ™ (3 μm)-water-soluble size-exclusion columns

SRT and Zenix column stationary phases adopt patented surface modification technology (patent US 7,247,387B1 and US 7,303,821B1), by bonding a uniform layer of nano-thick neutral hydrophilic on a high purity silica matrix with good mechanical stability Film.

● Adopt controllable chemical modification technology to ensure reliable reproducibility between columns;
● Well-designed large pore volume can ensure high separation capacity and excellent resolution;
● The hydrophilic coating on the surface is completely covered, which makes it have excellent column stability and extend the life of the column;
● Low salt concentration elution, suitable for LC-MS analysis;
● Patented surface modification layer to ensure the maximum recovery rate of samples;
● Widely applicable to the separation and detection of biomolecules and water-soluble polymers.

SRT and Zenix columns have a good effect on the detection of polymer impurities in water-soluble β-lactam antibiotics.

Mono GPC-oil-soluble size exclusion chromatography column

Mono GPC is based on highly cross-linked polystyrene / divinylbenzene (PS / DVB) particles with extremely narrow particle size and pore size distribution. The pore size distribution is uniform, so that the retention time and molecular weight in the analysis have an accurate linear relationship. Porous particles with a high degree of crosslinking have excellent chemical and physical stability, so the shape of the molecular weight calibration curve and the efficiency of the chromatographic column can be kept almost unchanged when the organic solvent is changed. Mono GPC packing has a large pore volume, which ensures high resolution for polymer separation.
Mono GPC has good effect on the detection of polymer impurities in fat-soluble β-lactam antibiotics.

Detection of polymer impurities of cefodizime sodium by Zenix-150 Good batch-to-batch reproducibility

Zenix SEC-150

material

Silica gel with hydrophilic film bonded on the surface

the size of granule

3 μm

Aperture (Ã…)

~ 150

Protein molecular weight range

500-150,000

Water soluble polymer
Molecular weight range

500-25,000

pH stability

2 – 8.5, short-term resistance to pH 8.5-9.5

Back pressure (7.8x300 mm)

~ 1,500 psi

Maximum withstand pressure (psi)

~ 4,500

Salt concentration range

20 mM-2.0 M

Maximum operating temperature (oC)

~ 80

Mobile phase compatibility

Conventional aqueous and organic phase solvents

Applications

Quality service

● Provide free product trial
● Provide chromatography screening and method confirmation of actual samples

Promotion announcement

From now until August 30, when you purchase one size exclusion chromatography column, the second size exclusion chromatography column can enjoy 50% discount or give away a high-end C18 column.
Note: The market price of the second size exclusion column should not be higher than that of the first.

Order information

About Racepoint Technology

Sepax Technologies, Inc. is headquartered in the Delaware High-Tech Development Zone, dedicated to the development and production of technologies and products in the field of separation and purification of pharmaceuticals and biological macromolecules. Saifen Technology is an industrial enterprise integrating R & D, production and global sales. The company's main products are liquid chromatography columns and consumables, solid phase extraction columns (SPE) and consumables, liquid chromatography packing and separation and purification equipment. In the field of liquid chromatography, Sepion Technology has developed more than 100 different types of liquid chromatography materials, covering reverse phase, normal phase, supercritical (SFC), chiral (Chiral), ion exchange, volumetric Resistance, affinity, HILIC and other categories are one of the most complete liquid chromatography products in the world.

The innovative technology of Saifian Technology enables it to produce the highest resolution and most efficient biological separation products, including size exclusion, ion exchange, antibody separation, and carbohydrate separation chromatography packing materials and chromatography columns, which can be widely used in single Analysis, isolation and purification of biological samples such as cloned antibodies, various proteins, DNA, RNA, peptides, polysaccharides and vaccines. The advanced technology and perfect product line of Saifen Technology have made Saifen a global leader in biological separation.

Company website:

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